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NPC Rapid Review Olmesartan reduces disease oriented outcomes but may have potential cardiovascular safety concerns Rapid reviews | Podcasts | Shared practice examples | Events | Publications and resources | FAQs | Email alerts | Newsroom | Contact us | A to Z found olmesartan delayed the onset of microalbuminuria in patients with type 2 diabetes and normoalbuminuria. While this disease-oriented outcome (DOO) suggested a potential benefit for olmesartan, of greater concern is that more patients taking olmesartan compared with placebo had fatal cardiovascular events � 15 patients (0.7%) vs. 3 patients (0.1%) (P=0.01).The authors of the current study state that RAS drug treatment may be beneficial in the early stages of type 2 diabetes, as ACE inhibitors have been shown to delay the onset of microalbuminuria in type 2 diabetes patients with hypertension but normoalbuminuria. Hence the rationale for this study, to ascertain whether the A2RA, olmesartan, could also be beneficial in delaying the onset of microalbuminuria in patients with type 2 diabetes and normoalbuminuria. The renal results from this study are interesting and add to the debate about the renal benefits of RAS drugs in people with type 2 diabetes. However, the onset and progress of microalbuminuria is a disease oriented outcome (DOO), and in itself does not tell us if patients are likely to live longer or better as a result of this (only measuring patient oriented outcomes [POOs] can tell us this). The main reason we are interested in this paper is because of the unexpected finding that olmesartan was associated with an increased risk of fatal CV events, a POO. Hydrochlorothiazide/olmesartan Reviews Ratings at Drugs.com A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Advanced Phonetic About 7 years ago, my cholestrol, BMI, BP were 260, 30, and 180/110, respectively. After 8 weeks of exercise, I lost 40 lb, new BMI =19. Cholestrol 170, BP=145/100. Started Toporol 25mg. A year later, added Benicar 20/12.5. I have a frequent side effect that Doctor doesn't understand: I call it GyaRel11am Syndrome. At around 11 am (after 3 hrs of intake of medicine), I feel bad. Hand/feet feel cold. I am confused. I rush to take lunch. In next 15 min, I am normal for whole day. Olmesartan Reviews Ratings at Drugs.com A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Advanced Phonetic My 65-yr-old-Darling-Husband takes Benicar for HTN; and even though I'm an RN, didn't know what would happen to a person taking Benicar who becomes run down Twice after burning the candle at both ends my DH had episodes of profuse sweating, a non-palpable pulse, and passed out v-low BP. Cardiologist finally said Benicar can cause zero BP. Benicar (olmesartan): Ongoing Safety Review Quick Links: Skip to main page content Skip to Search Skip to Topics Menu Skip to Section Content Menu Skip to Common Links [UPDATED 04/14/2011] After reviewing the results of the ROADMAP and ORIENT trials, FDA has determined that the benefits of Benicar continue to outweigh its potential risks when used for the treatment of patients with high blood pressure according to the drug label. Benicar is not recommended as a treatment to delay or prevent protein in the urine (microalbuminuria) in diabetic patients.: The Agency plans to review the primary data from the two studies of concern, ROADMAP and ORIENT, and is considering additional ways to assess the cardiovascular effects of Benicar.
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